Doctors and pharmacy employees usually recommend loratadine because compared to other antihistamines, this drug is said to be non-drowsy and safer. However, some manufacturers of loratadine mention sedation as one of its side-effects. So does this mean, loratadine is not Â‘non-drowsyÂ’ after all?
Health & Beauty
Pharmacy & Drugs
Antihistamines or anti-allergy drugs are regarded as the first-line of relief for symptoms of hay fever and skin allergies. There are two types of antihistamine drugs- the first generation and the second generation. While the old, FGA or first generation antihistamines (chlorphenamine, diphenhydramine etc.) include anti-allergies that induce drowsiness or sleepiness, the newer, SGA or the second generation antihistamines (loratadine, fexofenadine and cetirizine) are considered as non-sedating antihistamines.
Between the two types, the SGA drugs are regarded as safer because these have least CNS side effects. The FGA on the contrary, may increase the risk for vehicular accident and injuries at work.
Loratadine as a second generation antihistamine is popular for its non-drowse effect. Claritin, a brand name of loratadine even have a ‘no-drowse’ statement in its label. However, other loratadine brands such as Allerta (Amherst lab/ UAP), Lorahist (JustRight Pharma) and Lergicyl (Eurowest/ Basic Pharma) reveal sedation as an adverse reaction. So does this mean, loratadine is also a sedating allergy drug?
Loratadine is known as a long acting non-sedating antihistamine normally taken once a day. It is a non-prescription antihistamine or anti-allergy drug that can be taken with or without food.
Loratadine is indicated as a relief of symptoms of chronic urticaria and other skin allergy. It is also a drug of choice for symptoms associated with allergic rhinitis or hay fever as sneezing, nasal itching, ocular or eye itching.
Loratadine is classified as a tricyclic antihistamine, closely related to tricyclic antidepressants such as Amitriptylin (Elavil) and the antipsychotic quetiapene.
Common brand names and availability
As a single drug form:
Allerta syrup and tablet (UAP)
Claritin syrup and tablet (Schering-Plough)
Clarihist tablet (International Apex)
Flamitin tablet (Flamingo/ Pasteur Pharma)
Immunix tablet and syrup (Unique/ Ambica)
Lergicyl tab (Eurowest/ Basic Pharma)
Loratyne tab (New Smart Formulae)
Loraped syrup (Pediatrica)
Lorahist tab (Unison/ JustRight Pharma)
Lorano tab (PT Prma Hexal)
Zylohist tab (Zydus Cadilla/ GX International)
In combination form:
Claricort tab (loratadine with betamethasone ) (Schering-Plough)
Clarinase tablet and syrup (loratadine with pseudoephedrine) (Schering-Plough)
Common contraindications and special precautions
Loratadine is contraindicated with people who have hypersensitivity to the drug and those with liver problems. As for pregnancy, loratadine safety is still not established. Loratadine is excreted in milk thus; its antihistamine effect can also be obtained by the infant. Most doctors would prescribe loratadine for kids below two years old; however as an OTC drug its label or leaflet may include a precaution for kids under 2 years old.
Common adverse reactions
These include fatigue, somnolence, headache, dry mouth, gastrointestinal disorders as gastritis, nausea etc. and rare cases, allergic symptoms as rash. Other observed side- effects include alopecia, anaphylaxis, tachycardia and palpitations.
Common drug interactions
Loratadine causes toxicity when taken with amiodarone- anti arrhythmic drug and with nefazodone hydrochloride- a phenylpiperazine antidepressant. In addition, its plasma concentration may also increase with ketoconazole, erythromycin or cimetidine.
Loratadine as a less-sedating antihistamine drug
Tracing the origin of the drug, loratadine is a tricyclic antihistamine structurally related to Amitriptyline- a tricyclic antidepressant product which is also under the CNS stimulants. Tricyclic antidepressants are agents that are used to treat major depressions. These agents have two groups, the dimethylamino compounds which tend to be sedative and the monomethyl relatives that tend to be stimulatory. With Amitriptyline, this product is the most sedative of the tricyclic antidepressants. More to this, loratadine is also connected to antipsychotic quetiapene which is considered as the most sedating of all the anti-psychotic drugs.
Interestingly, what makes loratadine less sedating than other antihistamines is because it only penetrates the blood brain barrier a little. In the brand Claritin, 'the no significant sedative property' is cited at the daily recommended dose of 10 mg.
Taking loratadine safely
As a less-sedating anti-allergy drug, loratadine may also cause drowsiness. Individuals must also be advised that this inconvenience may occur and may affect tasks as driving or other activities that needs concentration. An interaction between alcohol and loratadine has not been shown; however, it is still best to avoid excessive liquor drinking while on loratadine medication.
Loratadine is an OTC drug, without the privilege of specific instructions from a physician. Do not hesitate to ask assistance from the pharmacist or pharmacy personnel to avoid over dosing particularly with loratadine liquid forms for kids.
Loratadine are for mild allergies only. In cases of serious conditions, a physician’s advice is the best. Like any other medications, loratadine may not be for you, observe yourself intently and if an untoward reaction occur, discontinue the medication and seek medical help as soon as possible.
© Phoenix Montoya @ March 8, 2011
PPDr 5th Edition
Wilson and Gisvold’s Textbook of Organic Medicinal and Pharmaceutical Chemistry 9th Edition
More articles by this author:
Breaking a Medicine Tablet: Is It Advisable?
Appetite Stimulant Facts
Expired Medication Cover-Ups
Add a comment
Just revisiting. Thank you.
Have a great weekend, my friend!
Your articles are all so well researched. Thank you Phoenix.
I've used these as well and they do what they say on the tin...
excellent write up!
Very informative article. Well done. Voted up.
Very helpful, I learned a lot from your article.
Voted up. Informative article
I have found some medicines that say Non Drowsy do make me
thanks for the wonderful info my friend
very informative article.
I have used claritin in the past and they are quite effective.
Another excellent medicinal information, kabayan.
As usual, you're the expert here. Nice to know about Loratadine
and its side effects.
Expert presentation as usual.
I think it depends on the person. It doesn't knock me out, but
it could do something different to somebody else. Medications are
funny in that way.
Very useful and comprehensive info on this drug.
Quadriderm cream or ointment contains betamethasone as 17 - valerate (0.05%), gentamicin sulfate (0.1%), Tolnaftate (1%) and clioquinol (1%).
Quadriderm cream or ointment - Tubes with 20 grams.
What is Quadriderm cream used for?
Quadriderm ointment or cream is a topical dermatol...
In the Philippines Chinese BL cream is categorized as a counterfeit drug – not that it is fake or ineffective, but simply it is an imported drug unregistered in the country’s Food and Drug Authority. Naturally, these products are banned in drugstores and other drug outlets. However, a Ch...
Disflatyl tablets uses and side effects
Active ingredients- Simethicone.
Disflatyl tablets amass the gas bubble formed in the stomach and intestine, helping easier routing of gas. It is prescribed for relief from pressure created by excessive formation of gas bubbles in the stomach and intestine.
In the Philippines, LS BL cream is imported and distributed by Manxing Enterprise Corporation from Shanghai Baolong Pharmaceutical Co. Ltd in China. LS BL cream is legal as it is registered in the Food and Drug Authority (FDA). Unfortunately, like the unregistered Chinese BL, there are also co...
In the Philippines, most cough remedies are considered as OTC or Over-The- Counter medications. Customers usually choose a product based on drug popularity. The more they see or hear about it from the media, the more they feel secure in purchasing the product for their loved ones or for themse...
Active ingredients present in Tuseran Forte- dextromethorphan HBr, phenylephrine HCl and paracetamol.
Dextromethorphan HBr, an anti-tussive, restrains the region in the brain that stimulates coughing. Phenylephrine HCl, a decongestant, loosens and clears airway passage allowing easie...
Surfaz SN Anti fungal, Antibacterial and Anti-inflammatory cream
• Clotrimazole I P 1.0% w/w
• BeclomethasoneD propionate IP 0.025% w/w
• Neomycin Sulphate I. P. 0.5% w/w
• Cream base. q.s.
• Mettiyi Paraben I. P. 0.15% w...
Zentel worm Medicine dosage and Side effects
Zentel active ingredients- Albendazole from the family of benzimidazole grouping of anthelmintic agents.
Albendazole is a white to off-white, neutral or approximately fragrance-free fine particles, which is virtually insoluble in H20 and somewhat so...
Active ingredient- Erdosteine
Ectrin indications/ uses
Ectrin (Erdosteine) is indicated for treating severe bronchitis, constant bronchitis as well as its exacerbations. It may as well be used for treating respiratory problems portrayed by uncharacteristic bronchial discharge ...
Diprogenta Cream (Betamethasone dipropionate)
Betamethasone is an artificial corticosteroid that is applied on the skin (topically). Betamethasone impersonates the effect of hydrocortisone (cortisol), the steroid generated naturally in the human system by the adrenal glands. Corticosteroids conta...
Grilinctus (Dextromethorphan Hydrobromide)
Grilinctus (Dextromethorphan Hydrobromide) is a pleasant tasting composition of proved therapeutic agents. It provides symptomatic relief from dry, irritating and allergic cough. Grilinctus (Dextromethorphan Hydrobromide) is a combination; and provides a p...
Taxim-O 200mg (cefixime)
Cefixime(Taxim-O) is an 3rd generation oral cephalosporin antibiotic. It is administered to take care of tonsilitis, gonorrhea, as well as pharyngitis. The normal dosage is 400 mg in 2 separate doses for a period of about one week.
Domstal Dosage and side effects
Domstal active ingredients- Domperidone and Cinnarizine .
Domstal Used for
• Treating motion sickness (nausea and/ or vomiting),
• Treating feeling of feeling heavy after meal,
• Treat heartburn, stomach discomfort and acidity, because of food ing...
Heraclene (Dibencozide) Capsule
Active ingredients- Dibencozide
Mechanism of action
Heraclene (Dibencozide) Capsule amplifies the protein "effectiveness coefficient" for example, the proportion of "bound nitrogen" for protein fabrication in the system evaluated to "consumed nitrogen" with foo...
Enzomac (Typsin, Bromelain & Rutoside Trihydrate) Tablets
Trpsin BP 48 Mg
Bromelain 90 Mg
Rutoside Trihydrate BP 100 Mg
Total proteolytic activity not less than 1095 FIP units per tablet. (Papain method).
Description- Enzomac contains a combination of two proteolytic enz...
Active ingredients- Na citrate, Diphenhydramine HCl and Menthol.
Composition/5 mL - Na citrate 28.5 mg, Diphenhydramine HCl 7 mg and menthol 0.55 mg
Amydramine syrup is a combination of Na citrate, Diphenhydramine HCl and Menthol and is from the group of am...
Whenever a customer asks for a cold and cough drug for an adult, Tuseran Forte is the first choice by most pharmacies. Aside from its convenient form as a capsule, Tuseran Forte contains phenylephrine – a decongestant; dextromethorphan – a cough suppressant; and paracetamol – an an...
Active ingredients- Betamethasone and dexchlorpheniramine maleate.
Celestamine belongs to the steroid family and works by inhibiting the production of compound in the body causing pain and inflammation.
Celestamine is administered for treating many health conditions which inc...
Kremil S side effects (Simethicone)
Kremil S is from the antacids family with antiflatulents. Kremil S binds the gas bubbles formed in the stomach together allowing easier passage of gas. They are administered for easing painful pressure due to excessive gas formation in the stomach and intestine. ...
Saridon Side effects
Active ingredients – Paracetamol
Saridon is administered for quick relief from pain and reducing fever associated to common cold and flu. Saridon (Paracetamol) is used to relief many conditions which includes migraine pain, headache, muscle ache, arthritis pain, backache...
Medicol is a popular brand name of ibuprofen, a NSAID or non-steroidal anti-inflammatory drug in the Philippines. It is similar with Midol, another notorious brand for ibuprofen. But, while Midol is known by most women as relief for PMS or pre-menstrual syndrome, Medicol has been popular for fever, ...
Chickenpox is a contagious disease caused by the varicella zoster virus. It can spread through the air and by direct contact. Chickenpox develops ten to twenty days after contact with an infected person. While its symptoms include fever and malaise, the itchy rash that turns into blisters is t...
Myonal (Eperisone) 50mg
Myonal active ingredients- Eperisone HCl
Besides Myonal tablets also has carmellose, carnauba wax, microcrystalline cellulose, stearic acid, titanium oxide, calcium stearate, talc, sucrose, macrogol 6000, precipitated calcium carbonate, white shellac, cornstarch, hydroxy...
Fluocinonide is a recognized topical medication for various skin disorders usually applied 2 to 3 times a day. It is categorized as a corticosteroid useful for dermatitis, psoriasis, eczema and for other allergic skin inflammation. Although, popular as an ointment, fluocinonide can also ...
Salicylic acid is something to be associated to acetylsalicylic acid (ASA) also known as aspirin since it is a component of this medication. While a small amount of salicylic acid can be employed as a food preservative, it is commonly used as a topical medication for skin disorders like psoriasis, w...
Lagaflex (carisoprodol) belongs to the group of muscle relaxing drug that functions by thwarting pain feelings involving the nerves as well as the brain.
Carisoprodol is administered along with rest and objective treatment to take care of injuries and supplementary excrucia...
Silverex Cream (silver sulfadiazine)
Silverex Cream (silver sulfadiazine) is from the family of topical sulfonamides applied for treating a wide range of dermatological diseases.
Silverex Cream uses
Silverex cream is used for treating as well as preventing infectivity in acu...
Enervon C Multivitamin Supplement
Enervon C multivitamins are an amalgamation of a variety of vitamins and minerals that are regularly found in our daily food and other normal sources. Multivitamin are prescribed for treating deficiency of vitamins caused by illness like pregnancy, unhealthy nutri...
Active ingredients- 250 mg of Fe gluconate, 7.5 mcg of vitamin B12, 50 mg of vitamin C, 1 mg of folic acid, 25 mg of sorbitol, 200 mcg of copper sulfate, 200 mcg of manganese sulfate.
Sangobion indications/ uses
Sangobion capsules are prescribed or administered for treati...
composition - Dorflex
Each tablet contains:
Orphenadrine citrate 35 mg, Dipyrone 300 mg, Caffeine 50 mg
Each ml contains:
Orphenadrine citrate 35 mg, Dipyrone 300 mg, Caffeine 50 mg
Patient information - Dorflex
Store in a cool place and pr...
Antihistamines or anti-allergy drugs are regarded as the first-line of relief for symptoms of hay fever and skin allergies. There are two types of antihistamine drugs- the first generation and the second generation. While the old, FGA or first generation antihistamines (chlorphenamine, diphenhydrami...
Secnidazole side effects
The most common side effects of imidazole derivatives are digestive problems like nausea, stomach pain, abnormal taste (metallic), glossitis and stomatitis. Have rarely been reported: skin rashes, mild leukopenia (reversible after discontinuation of treatment), dizziness, p...
Althrocin 250 Mg/ 500 Mg (Erythromycin)
Althrocin (Erythromycin) belongs to a group of macrolide antibiotic that has an antimicrobial range comparable to or to some degree larger than that of penicillin, and is frequently administered for patients allergic to penicillin. For respiratory tract conta...
Fucicort Topical Cream
Active ingredients: Fusidic Acid 2 % and betamethasone valerate 0.1 %
Fucicort Topical cream belongs to the group of potent (group III) corticosteroids, along with antibiotics. Fusidic acid works as the active anti-bacterial component of Fucicort Cream which performs its an...
Active ingredients- Phenylpropanolamine and Paracetamol.
Per capsule-phenylpropanolamine 25 mg and Paracetamol 325 mg.
Per 5 mL syrup- Paracetamol 240 mg and Phenylpropanolamine HCl 12.5 mg
Nasathera is from the family of systemic sympathomimetic preparatio...
Different vitamins found in our natural food are combined together to form multivitamins. When the regular meal fails to provide the required nutrients to the body multivitamin supplements are prescribed. In short Multivitamins are medicines use for treatment of vitamin defici...
Antamin (Chlorphenamine maleate)
Active ingredients- Chlorphenamine maleate
Antamin (Chlorphenamine maleate) belongs to the group of alternate alkylamines administered as general antihistamines.
The drug assists to alleviate signs of cold as well as allergy, lik...
Active ingredients- Acetylcysteine
Fluimucil (Acetylcysteine) is from the group of mucolytics administered for treating wet cough.
Fluimucil (Acetylcysteine) uses/ indications
It may be indicated for treating severe and chronic respiratory tract infection with plenty o...
Alvedon (Paracetamol) 500mg tablet
Active ingredients- paracetamol
Despite being used for over 100 years, research haven’t yet being able to understand the working of paracetamol, however it is presumed that Alvedon (Paracetamol) 500mg works by decreasing the secretion of prostaglandins in t...
While some people perform strenuous exercises or take diet pills to lose weight, there are also individuals who would want to gain extra pounds. Athletes for instance, would want more muscles and to do that they must take a lot of protein enriched foods. Parents would want their kids to eat more to ...
A lot of antitussive agents today act centrally and causes central adverse events such as sedation, vomiting, and nausea. Because of this, there has been a search for a peripherally-acting antitussive agent expected to not produce these central adverse effects. However, the peripherally-acting antit...
Ambroxol (mucosolvan) side effects
Ambroxol Hydrochloride is an effective expectorant administered for various respiratory problems. It is a medically proven active mucolytic agent. Ambroxol is used for treating respiratory tract infections and other lung infections, which includes inflammatory pul...
Methycobal Tablets (Mecobalamin 500 mcg)
Each Methycobal sugar coated Tablet contains: Mecobalamin 500 mcg (Appropriate overages added) Color: Titanium Dioxide
Methycobal is a mecobalamin drug, a co-enzyme of Vitamin B that transpires in the blood and the cerebrospinal fluid. It is utilized by the...
Biogesic (paracetamol) Side effects
Paracetamol is the generic name for Biogesic and use for treating moderate to severe pain, headache, fever, arthritis pain, and muscle ache. Biogesic tablets, though, does not alleviate the hardness, reddishness and inflammation linked to rheumatoid arthritis, bu...
Active ingredients- Paracetamol and Ibuprofen
Ibuprofen is a powerful anti-inflammatory with painkilling and antipyretic activity. Its antipyretic and analgesic actions are additionally reinstated by paracetamol.
Combiflam Adverse Reactions
Combiflam Side Eff...
SORBILINE (SORBITOL SOLUTION)
Each 10 ml of SORBILINE contains :
TR1CHOL1NE CITRATE 0.55 g
SORBITOL SOLUTION (70%) I.P. 7.15 g
Color : Sunset Yellow FCF (Colour Index 15985)
Elica cream (mometasone furoate cream)
Elica (mometasone furoate) Cream, 0.1%, is made up of mometasone furoate, USP for dermatologic use. Mometasone furoate is a artificial corticosteroid with anti- seditious action.
Each gram of Elica Cream, 0.1%, comprises: 1 mg mometasone furoate, USP in a c...
There are a lot of options available when you need to fill a prescription. Grocery store chains, superstore chains and traditional drug stores are on practically every block, ready, willing and able to supply you with your medicinal needs and good advice.
Comparing superstore and traditional ...
In various disorders such as acute and chronic bronchitis and other bronchospastic disorders such as eosinophilia, there is a spasm of the bronchial muscles and irritation of the bronchial mucous membrane, leading to breathlessness and cough. In the symptomatic management of these di...
Erythromycin is a drug of choice in a case when a patient is allergic to penicillin. However, using the same antibiotic may result to tolerance. Here are other antibiotic alternatives that are often prescribed by physician in replacement for Erythromycin.
Josamycin has been marke...