LS BL: Antifungal Corticosteroid Cream

LS BL cream seems to be an improved form of Chinese BL - a popular antifungal agent more recognized for its whitening effect. Contrary to this, LS BL has the same content as Chinese BL cream. With the recent research of the author, it has been found out that Chinese BL not only possesses ketoconazole but clobetasole as well. In the Philippines, LS BL cream is a registered form of Chinese BL cream. Interestingly, similar to Chinese BL, LS BL cream can also be bought anywhere. This is a review about LS BL cream and some warnings.

In the Philippines, LS BL cream is imported and distributed by Manxing Enterprise Corporation from Shanghai Baolong Pharmaceutical Co. Ltd in China. LS BL cream is legal as it is registered in the Food and Drug Authority (FDA).  Unfortunately, like the unregistered Chinese BL, there are also counterfeit LS BL creams.

LS BL cream facts

Similar to the Chinese BL cream, LS BL has ketoconazole with the corticosteroid clobetasol. LS BL is a combination of a 10mg/g ketoconazole and a 500mcg/g clobetasol. Like the Chinese BL, LS BL is a 7g cream contained in a maroon jar.

LS BL is a prescription topical preparation indicated for fungal infections including tinea cruris (jock itch), tinea corporis (ringworm), tinea pedis (athlete’s foot) etc. Because it also contains clobetasol, LS BL can be a lot helpful when the itching and inflammation are severe.

More to this, LS BL is cited to be effective for dermatitis like seborrhoeic dermatitis, atopic dermatitis or eczema and psoriasis.

LS BL is applied one to two times daily.

Dangers

LS BL cream is contraindicated to individuals who have allergies to its components. Although, it is only applied over the skin, LS BL cream can also reach the systemic circulation. It should not be used for a long period of time or applied in the large area of the body. LS BL is to be used in precaution in pregnant and breastfeeding mothers.

Infants and children are apt to have LS BL cream into the bloodstream because they have larger skin area to body weight ratio in comparison to the adults. Newborns or premature babies can also absorb high quantities of clobetasole because of the incomplete development of the stratus corneum – the outermost layer of the skin.

With ketoconazole alone, any topical agent with this active constituent is an OTC or over-the-counter product. But, because LS BL cream contains clobetasole it is categorized as a prescription medicine.

Clobetasole is a corticosteroid and as a steroid it can cause cushing syndrome, intracranial hypertension and growth retardation in children.  More to this, prolonged use of a potent topical corticosteroid like clobetasole or a preparation containing this active constituent can cause cataract, diabetes mellitus, glaucoma and tuberculosis.

Whitening effect?

Similar to the Chinese BL, LS BL cream is not indicated for skin lightening or whitening effect. LS BL is primarily indicated for fungal infections.

Image by the author

Recommendations and warnings

As mentioned LS BL cream is more legal than the Chinese BL cream in the Philippines. LS BL cream was registered in the FDA (Food and Drug Authority) Philippines since December 2012 under the DR number DR-XY40466.

However, because LS BL is also popular like the Chinese BL, it is usually imitated. The photo of LS BL cream above was a purchase of the author from a grocery store. Interestingly, the clerk was selling it for its whitening benefits, unmindful that LS BL cream is a prescription drug.

LS BL cream, similar to the Chinese BL has clobetasole. A topical preparation containing corticosteroid should not be used for over two weeks. It is frightening that some women use LS BL cream as a beauty lotion. LS BL like Chinese BL is primarily for fungal infections. As LS BL cream contains clobetasole propionate, an advice from a registered physician is essential.

Finally, since LS BL cream is FDA approved. Consumers should only buy this product in registered drug outlets to avoid a counterfeit or fake LS BL cream.

© Phoenix Montoya @ January 28, 2013

References:

  1. LS BL cream leaflet
  2. Clobetasole leaflet
  3. http://www.fda.gov.ph/database/k.pdf
  4. http://www.mayoclinic.com/health/seborrheic-dermatitis/DS00984/DSECTION=causes

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What is Quadriderm cream used for? Quadriderm ointment or cream is a topical dermatological preparation highly effective in treating many skin disorders. Quadriderm cream or ointment should be stored in a cool place and protected from light and moisture. The validity of Quadriderm ointment or cream is 36 months, and is recorded on the outer packaging, in case of expiration render the product unusable.

Quadriderm cream

Quadriderm cream or ointment contains betamethasone as 17 - valerate (0.05%), gentamicin sulfate (0.1%), Tolnaftate (1%) and clioquinol (1%).

Quadriderm cream or ointment - Tubes with 20 grams.

What is Quadriderm cream used for?

Quadriderm ointment or cream is a topical dermatological preparation highly effective in treating many skin disorders.

Quadriderm cream or ointment should be stored in a cool place and protected from light and moisture.

The validity of Quadriderm ointment or cream is 36 months, and is recorded on the outer packaging, in case of expiration render the product unusable.

Tell your doctor the occurrence of pregnancy during treatment or after its termination. Inform your doctor if you are breastfeeding. Follow the advice of your doctor, always respecting the schedules, doses and duration of treatment. Do not stop treatment without the knowledge of your doctor. Tell your doctor the appearance of unpleasant reactions such as burning, itching, irritation and dry skin. Tell your doctor about any medication you are using before the start or during treatment.

Quadriderm ointment or cream is not suitable for ophthalmic use.

TECHNICAL INFORMATION - Quadriderm

Quadriderm cream or ointment is a topical dermatological preparation highly effective in treating many skin disorders. Quadriderm ensures greater safety of therapeutic success, especially when the causative agent cannot be readily identified.

Because it is a composition of four agents with different pharmacological effects, Quadriderm provides anti-inflammatory, antibacterial and antifungal in the treatment of inflammatory and allergic skin disorders complicated by some types of bacteria or fungi, including Candida.

Quadriderm cream uses

Quadriderm is indicated for topical use in dermatoses caused, complicated or threatened by some types dde bacterial or fungal infection, including candidiasis. It is indicated for the prevention and treatment of infections caused by bacteria or fungi in a variety of eczema and other allergic and inflammatory dermatoses. It has been used successfully to treat acne inguinal, chronic dermatoses of the extremities, erythrasma the external ear otitis, balanoposthitis, herpes zoster, dermatitis, eczema, contact dermatitis, dermatitis microbial follicular dermatitis, dyshidrosis, paronychia (candida) anal pruritus, intertrigo, seborrheic eczema, parakeratosis, pustular acne, impetigo of the scalp, neurodermatitis, angular stomatitis, seborrheic dermatitis, occipital area, photosensitivity dermatitis, lichenified and groin ringworm ringworm infections, like tinea cruris, tinea pedis, and tinea corporis.

CONTRAINDICATIONS - Quadriderm

Quadriderm cream or ointment is contraindicated in patients with a history of hypersensitivity to any of its components. It is also contraindicated in cases of tuberculous lesions of the skin, acute herpes simplex, vaccinia and varicella.

WARNINGS - Quadriderm

any adverse effects reported to the systemic application of corticosteroids, which include adrenal suppression, may also take place with topical corticosteroids, especially in children and newborns.

The absorption of Quadriderm cream or ointment will be larger if wide body surface are treated or if the occlusive method is used. Possible safety measures ought to be taken in advance in these situations or when it is prolonged use of the product, particularly in young children.

Prolonged use of topical antibiotics may occasionally result in growth of non-susceptible organisms. If this occurs, or if irritation, sensitization or super infections are present, treatment with Quadriderm cream or ointment should be discontinued and appropriate therapy should be instituted.

The ferric chloride test for phenylketonuria may yield false positive if clioquinol is present in the urine.

Light stains on clothing may occur due to clioquinol.

Quadriderm cream or ointment is not suitable for ophthalmic use.

Ascof and Solmux: A Comparison of Two Cough Remedies

A comparison between the herbal medicine Ascof and the synthetic cough cure Solmux – two popular cough remedy the Philippines. Is Ascof better than Solmux?

In the Philippines, most cough remedies are considered as OTC or Over-The- Counter medications. Customers usually choose a product based on  drug popularity. The more they see or hear about it from the media, the more they feel secure in purchasing the product for their loved ones or for themselves.

 Ascof and Solmux are two common cough cures. While Ascof is known as a herbal remedy, Solmux as a carbocisteine is also notorious for being in the market for 50 years as a mucoregulator in respiratory diseases  since the 1960s. Both claim efficacy and safety, but which of the two is really better?

Ascof

 

Image by the author

Manufactured by Pascual/ Altermed, Ascof (Lagundi) is from a herbal source. It is indicated for bronchospasm in acute bronchial asthma, chronic bronchitis and other bronco pulmonary disorder.

Contraindication: No known contraindication.

Precaution: Pregnancy and lactation.

Side-effect: Itchiness, nausea and vomiting, tachycardia, diarrhea, drowsiness and body malaise.

Solmux 

Image by the author

Solmux (Carbocisteine) is a derivative of cysteine which is an amino acid. It is manufactured by Westmont/ Unilab Consumer Health and its primary use is to reduce the viscosity of pulmonary secretions in patients. It is for wet productive coughs, to help eliminate phlegm.

Contraindication: Peptic ulcer.

Side-effect: GI disturbance, GI bleeding, headache, skin rash.

Ascof and Solmux comparison

  • Formulation

Ascof and Solmux have different formulations. Ascof is available in 300mg tablet, 600mg caplet and in 300mg syrup drug form. It contains powdered Lagundi leaves (Vitex negundo linne family Verbenaceae). Ascof is for mild to moderate cough usually associated with common colds.

Solmux is available in 500mg capsule and in suspension forms. It has a mucolytic property. It is more beneficial in eliminating excessive mucous in the lungs.

  • Relief

Solmux in its encapsulated form has faster effect than Ascof tablet. Capsule forms of medications have greater dissolution compared to tablets thus they have faster relief. On the other hand, syrup has faster effect than suspension types. This means, Ascof syrup has a much faster effect than Solmux suspension.

  • Safety

Ascof reveals some mild side effects on few patients like itchiness, vomiting etc. These adverse reactions as they claim were reported without prevailing complaint with similar frequency on the placebo control. Solmux’s adverse effect involves gastric upsets. This drug is also used in precaution with old people with severe respiratory insufficiency or asthmatic patients.

Ascof VS Solmux

Considering the formulation, Ascof is more attractive for most consumers because of its herbal origin.  As for relief, liquid forms of medication have faster action and both Solmux and Lagundi have these dosage forms. Although, in terms of solid preparations, Solmux capsule is better than Ascof tablet.

Regarding safety, Ascof has no known contraindications and has mild adverse reactions that are reported rarely. However like most drugs, it is used in precaution with pregnant women and in lactation. Solmux on the other hand, causes stomach upsets, thus strictly contraindicated to people with peptic ulcer. More to this, it is also to be used in precaution with old people with weak lungs or asthmatic patients.

So which is better?

Summing it up, Ascof may have all the advantages over Solmux. But, these drugs possess dissimilar modes of action. Solmux is a mucolytic while Ascof is a simple cough formula with an anti-asthma effect. Ascof won’t be effective enough if the cough will be involving too much phlegm in the lungs. On the contrary, Solmux will not be also suitable for a simple cough with asthma involved.

References:

MIMS online

Dovepress

Wilson and Gisvold’s Textbook of Organic Medicinal and Pharmaceutical Chemistry 9th edition

Disflatyl Uses and Side Effects

Disflatyl tablets uses and side effects. Active ingredients- Simethicone. Disflatyl tablets amass the gas bubble formed in the stomach and intestine, helping easier routing of gas. It is prescribed for relief from pressure created by excessive formation of gas bubbles in the stomach and intestine.

Disflatyl tablets uses and side effects

Active ingredients- Simethicone.

Disflatyl tablets amass the gas bubble formed in the stomach and intestine, helping easier routing of gas. It is prescribed for relief from pressure created by excessive formation of gas bubbles in the stomach and intestine.

Disflatyl tablets may be prescribed for ailments not listed above.

Dosage

Adults For functional gastric disorder, postoperative Gas Pains and Flatulence: 40 to 125 Mg of Simethicone to be administered orally after meal and at bedtime.

Adults for Endoscopy: 67 Mg of Simethicone as an oral suspension administered just before Endoscopy.

Disflatyl tablets side effects

Rare cases of side effects associated to Disflatyl tablets have been reported. In case any of these side effects occur, seek for immediate medical help. Symptoms include extreme allergic reaction; skin irritation, hives skin rashes, redness, difficulty in breathing, swelling, and chest pain, chest congestion, swelling of the face, lips tongue or throat.

Common side effects include headache, nausea, vomiting, constipation, diarrhea and abdominal cramps. Consult a doctor if any of these side effects of Disflatyl tablets become persistent and troublesome.

Important information on Disflatyl tablets

• Avoid the medication if you are allergic to Simethicone.

• Use the medication after taking your meal at bedtime or follow the instructions prescribed by your doctor. It is important to maintain your diet prescribed by your doctor along with using the medication for effective results. Consult with your doctor the list of food you need to avoid for controlling the ailments.

• Simethicone may interact with other drugs and cause severe side effects, inform your doctor if you are using any other drug, vitamin supplement or herbal remedies for prevailing ailments.

• Avoid using over the counter medication without consulting with your doctor.

• Consult with your doctor before using Disflatyl tablets in case of pregnancy or breast-feeding.

• Avoid overdose; strictly follow the instruction prescribed to you by your doctor. In case of overdose, seek for immediate medical help.

• Store Disflatyl tablets at room temperature away from direct sunlight, hear and moisture. Keep it safely out of reach of children.

• Disflatyl tablets may cause drowsiness, avoid using it while driving or operating heavy machinery.