Simvastatin is known as a cholesterol-lowering drug. In the Philippines, it is the widely used anti-cholinesterase and the most recommended by most doctors. Here are facts about simvastatin Â– its uses, side-effects and safety.
Health & Beauty
Pharmacy & Drugs
Simvastatin was popularly recognized as Zocor. Nowadays, with the rise of numerous cheaper brands and generic equivalent competitors, most people understood simvastatin simply as cholesterol–lowering drug.
Simvastatin is an antihyperlipidaemic agent. As a statin or HMG CoA reductase inhibitor, simvastatin reduces the LDL (low-density lipoprotein) or the bad cholesterol. It also decreases the triglycerides in the blood while increasing the HDL (high-density lipoprotein) or the good cholesterol.
The following are more facts about simvastatin- its uses, side-effects and safety.
High cholesterol and triglycerides in the blood can be reduced through necessary diet and exercise. However, when these non-pharmacological measures do not work, medical experts prescribe statins like simvastatin to prevent the incidence of uncontrollable hypertension, coronary heart disease and stroke. Simvastatin is also indicated for familial hypercholesterolemia – a genetic disorder of high LDL (bad cholesterol) that is passed down through families.
Simvastatin is given at night before bedtime. Depending on the blood cholesterol level, simvastatin can be prescribed from 5mg to 10mg initially. The dose adjustment can be increased after a month if treatment is not acquired. Maximum dosing of simvastatin is 80mg.
Some brand names and availability:
Afordel (Merck) 20mg and 40mg tablet
Orovas (Pharma Nutria) 20mg and 40mg tablet
Simvahex (Hexal) 10mg, 20mg and 40mg tablet
Zave (Pharmatrix corp) 10mg, 20mg and 40mg tablet
Zocor (Merck sharp and Dohme) 10mg, 20mg, 40mg and 80mg
- Simvastatin common side-effects
Like any medication, untoward reactions can be expected from simvastatin. Common side-effects includes fever, headache, muscle and joint pain, stomach pain, constipation, rashes, insomnia and cold symptoms as stuffy nose and sore throat.
Simvastatin is contraindicated with individuals who have liver problems and with those who are allergic to its active constituent or excipients. There are reports on congenital malformations because of exposure to HMG- CoA reductase inhibitors therefore simvastatin is not advised for pregnant women. Since, simvastatin may have a potential adverse effect on infants and it is also excreted in breast milk, treatment with simvastatin while breastfeeding is also not recommended.
Simvastatin is not indicated for children under ten years old.
Itraconazole ketoconazole, erythromycin, clarithromycin, HIV protease inhibitors, cyclosporine or nefazodone, fibrates (except fenofibrate), niacin, amiodarone, verapamil, diltiazem with simvastatin can increase the risk of myopathy.
Warfarin or acenocoumarol with simvastatin can cause bleeding complications.
Simvastatin and myopathy:
Just recently, the FDA recommended an additional info for Zocor label, citing new restrictions, contraindications and dose limitations. Since, Zocor is a brand of simvastatin; the warning also applies to all simvastatin equivalents and simvastatin containing drugs as Vytorin (simvastatin + ezetimibe) and Simcor (simvastatin + niacin).
Simvastatin as a HMG- CoA reductase inhibitor occasionally causes myopathy - a degenerative skeletal muscle disease, manifested by muscle pain or weakness associated by high CPK (creatinine phosphokiase).
Rhabdomyolysis is the serious form of myopathy. Rhabdomyolysis can be a rare case but this form can be very fatal. Rhabdomyolysis can injure the kidneys that can lead to its malfunction.
Although, the risk of myopathy is usually observed with medicine interactions, the strength of simvastatin is now regarded. Simvastatin with the 80mg dose has higher incidence of myopathy. This potency should not be indicated for individuals new to simvastatin treatment or for those who are already using lesser strength of simvastatin. However, Simvastatin 80 mg can be continued with patients who have been taking it for 12 months or more, without the evidence of muscle injury.
Simvastatin 80 is normally used for patients with severe hypercholesterolemia and cardiovascular disease not corrected with the 40mg strength.
© Phoenix Montoya @ June 28, 2011
PPDr 5th edition
Simvastatin (Simvas) drug insert
Image thumb source
More articles by this author:
Add a comment
Impressive review. Thanks
An informative pharmaceutical review, mate. :)
excellent, I am on that medication for cholesterol
Very informative article. Voted up.
Great article about this drug, which a lot of people are using.
Promoted since I'm out of votes.
Really good share and excellent presentation. Thanks for sharing
I took Zocor for awhile. I love when you review medicines. The
information is comprehensive but easy to understand.
Great article. No doubt I've seen this drug advertised on
Another indispensable knowledge, kabayan. I had been using
simvastatin for two years now and had a slight indication of liver
inflammation after undergoing ultrasound. I still have to consult
my doctor about stopping taking this drug or otherwise.
Thanks Phoenix, very important information regarding Simvastatin
I had not heard of this, good information though for those who
should be aware.
Another great write up as usual!
important information for those with cholesterol conditions -
good to know more about one's medicine. voted up!
nice learning new things about medicine,keep it up my friend
As always, you made a great review on this drug. I learnt much
from you. Thanks, Phoenix!
Hmmnn...very educative and every inch information loaded. Thanks
Quadriderm cream or ointment contains betamethasone as 17 - valerate (0.05%), gentamicin sulfate (0.1%), Tolnaftate (1%) and clioquinol (1%).
Quadriderm cream or ointment - Tubes with 20 grams.
What is Quadriderm cream used for?
Quadriderm ointment or cream is a topical dermatol...
In the Philippines Chinese BL cream is categorized as a counterfeit drug – not that it is fake or ineffective, but simply it is an imported drug unregistered in the country’s Food and Drug Authority. Naturally, these products are banned in drugstores and other drug outlets. However, a Ch...
Disflatyl tablets uses and side effects
Active ingredients- Simethicone.
Disflatyl tablets amass the gas bubble formed in the stomach and intestine, helping easier routing of gas. It is prescribed for relief from pressure created by excessive formation of gas bubbles in the stomach and intestine.
In the Philippines, LS BL cream is imported and distributed by Manxing Enterprise Corporation from Shanghai Baolong Pharmaceutical Co. Ltd in China. LS BL cream is legal as it is registered in the Food and Drug Authority (FDA). Unfortunately, like the unregistered Chinese BL, there are also co...
In the Philippines, most cough remedies are considered as OTC or Over-The- Counter medications. Customers usually choose a product based on drug popularity. The more they see or hear about it from the media, the more they feel secure in purchasing the product for their loved ones or for themse...
Active ingredients present in Tuseran Forte- dextromethorphan HBr, phenylephrine HCl and paracetamol.
Dextromethorphan HBr, an anti-tussive, restrains the region in the brain that stimulates coughing. Phenylephrine HCl, a decongestant, loosens and clears airway passage allowing easie...
Surfaz SN Anti fungal, Antibacterial and Anti-inflammatory cream
• Clotrimazole I P 1.0% w/w
• BeclomethasoneD propionate IP 0.025% w/w
• Neomycin Sulphate I. P. 0.5% w/w
• Cream base. q.s.
• Mettiyi Paraben I. P. 0.15% w...
Zentel worm Medicine dosage and Side effects
Zentel active ingredients- Albendazole from the family of benzimidazole grouping of anthelmintic agents.
Albendazole is a white to off-white, neutral or approximately fragrance-free fine particles, which is virtually insoluble in H20 and somewhat so...
Active ingredient- Erdosteine
Ectrin indications/ uses
Ectrin (Erdosteine) is indicated for treating severe bronchitis, constant bronchitis as well as its exacerbations. It may as well be used for treating respiratory problems portrayed by uncharacteristic bronchial discharge ...
Grilinctus (Dextromethorphan Hydrobromide)
Grilinctus (Dextromethorphan Hydrobromide) is a pleasant tasting composition of proved therapeutic agents. It provides symptomatic relief from dry, irritating and allergic cough. Grilinctus (Dextromethorphan Hydrobromide) is a combination; and provides a p...
Diprogenta Cream (Betamethasone dipropionate)
Betamethasone is an artificial corticosteroid that is applied on the skin (topically). Betamethasone impersonates the effect of hydrocortisone (cortisol), the steroid generated naturally in the human system by the adrenal glands. Corticosteroids conta...
Taxim-O 200mg (cefixime)
Cefixime(Taxim-O) is an 3rd generation oral cephalosporin antibiotic. It is administered to take care of tonsilitis, gonorrhea, as well as pharyngitis. The normal dosage is 400 mg in 2 separate doses for a period of about one week.
Domstal Dosage and side effects
Domstal active ingredients- Domperidone and Cinnarizine .
Domstal Used for
• Treating motion sickness (nausea and/ or vomiting),
• Treating feeling of feeling heavy after meal,
• Treat heartburn, stomach discomfort and acidity, because of food ing...
Heraclene (Dibencozide) Capsule
Active ingredients- Dibencozide
Mechanism of action
Heraclene (Dibencozide) Capsule amplifies the protein "effectiveness coefficient" for example, the proportion of "bound nitrogen" for protein fabrication in the system evaluated to "consumed nitrogen" with foo...
Enzomac (Typsin, Bromelain & Rutoside Trihydrate) Tablets
Trpsin BP 48 Mg
Bromelain 90 Mg
Rutoside Trihydrate BP 100 Mg
Total proteolytic activity not less than 1095 FIP units per tablet. (Papain method).
Description- Enzomac contains a combination of two proteolytic enz...
Active ingredients- Na citrate, Diphenhydramine HCl and Menthol.
Composition/5 mL - Na citrate 28.5 mg, Diphenhydramine HCl 7 mg and menthol 0.55 mg
Amydramine syrup is a combination of Na citrate, Diphenhydramine HCl and Menthol and is from the group of am...
Whenever a customer asks for a cold and cough drug for an adult, Tuseran Forte is the first choice by most pharmacies. Aside from its convenient form as a capsule, Tuseran Forte contains phenylephrine – a decongestant; dextromethorphan – a cough suppressant; and paracetamol – an an...
Active ingredients- Betamethasone and dexchlorpheniramine maleate.
Celestamine belongs to the steroid family and works by inhibiting the production of compound in the body causing pain and inflammation.
Celestamine is administered for treating many health conditions which inc...
Kremil S side effects (Simethicone)
Kremil S is from the antacids family with antiflatulents. Kremil S binds the gas bubbles formed in the stomach together allowing easier passage of gas. They are administered for easing painful pressure due to excessive gas formation in the stomach and intestine. ...
Saridon Side effects
Active ingredients – Paracetamol
Saridon is administered for quick relief from pain and reducing fever associated to common cold and flu. Saridon (Paracetamol) is used to relief many conditions which includes migraine pain, headache, muscle ache, arthritis pain, backache...
Medicol is a popular brand name of ibuprofen, a NSAID or non-steroidal anti-inflammatory drug in the Philippines. It is similar with Midol, another notorious brand for ibuprofen. But, while Midol is known by most women as relief for PMS or pre-menstrual syndrome, Medicol has been popular for fever, ...
Chickenpox is a contagious disease caused by the varicella zoster virus. It can spread through the air and by direct contact. Chickenpox develops ten to twenty days after contact with an infected person. While its symptoms include fever and malaise, the itchy rash that turns into blisters is t...
Myonal (Eperisone) 50mg
Myonal active ingredients- Eperisone HCl
Besides Myonal tablets also has carmellose, carnauba wax, microcrystalline cellulose, stearic acid, titanium oxide, calcium stearate, talc, sucrose, macrogol 6000, precipitated calcium carbonate, white shellac, cornstarch, hydroxy...
Fluocinonide is a recognized topical medication for various skin disorders usually applied 2 to 3 times a day. It is categorized as a corticosteroid useful for dermatitis, psoriasis, eczema and for other allergic skin inflammation. Although, popular as an ointment, fluocinonide can also ...
Salicylic acid is something to be associated to acetylsalicylic acid (ASA) also known as aspirin since it is a component of this medication. While a small amount of salicylic acid can be employed as a food preservative, it is commonly used as a topical medication for skin disorders like psoriasis, w...
Lagaflex (carisoprodol) belongs to the group of muscle relaxing drug that functions by thwarting pain feelings involving the nerves as well as the brain.
Carisoprodol is administered along with rest and objective treatment to take care of injuries and supplementary excrucia...
Silverex Cream (silver sulfadiazine)
Silverex Cream (silver sulfadiazine) is from the family of topical sulfonamides applied for treating a wide range of dermatological diseases.
Silverex Cream uses
Silverex cream is used for treating as well as preventing infectivity in acu...
Enervon C Multivitamin Supplement
Enervon C multivitamins are an amalgamation of a variety of vitamins and minerals that are regularly found in our daily food and other normal sources. Multivitamin are prescribed for treating deficiency of vitamins caused by illness like pregnancy, unhealthy nutri...
Active ingredients- 250 mg of Fe gluconate, 7.5 mcg of vitamin B12, 50 mg of vitamin C, 1 mg of folic acid, 25 mg of sorbitol, 200 mcg of copper sulfate, 200 mcg of manganese sulfate.
Sangobion indications/ uses
Sangobion capsules are prescribed or administered for treati...
composition - Dorflex
Each tablet contains:
Orphenadrine citrate 35 mg, Dipyrone 300 mg, Caffeine 50 mg
Each ml contains:
Orphenadrine citrate 35 mg, Dipyrone 300 mg, Caffeine 50 mg
Patient information - Dorflex
Store in a cool place and pr...
Antihistamines or anti-allergy drugs are regarded as the first-line of relief for symptoms of hay fever and skin allergies. There are two types of antihistamine drugs- the first generation and the second generation. While the old, FGA or first generation antihistamines (chlorphenamine, diphenhydrami...
Secnidazole side effects
The most common side effects of imidazole derivatives are digestive problems like nausea, stomach pain, abnormal taste (metallic), glossitis and stomatitis. Have rarely been reported: skin rashes, mild leukopenia (reversible after discontinuation of treatment), dizziness, p...
Althrocin 250 Mg/ 500 Mg (Erythromycin)
Althrocin (Erythromycin) belongs to a group of macrolide antibiotic that has an antimicrobial range comparable to or to some degree larger than that of penicillin, and is frequently administered for patients allergic to penicillin. For respiratory tract conta...
Fucicort Topical Cream
Active ingredients: Fusidic Acid 2 % and betamethasone valerate 0.1 %
Fucicort Topical cream belongs to the group of potent (group III) corticosteroids, along with antibiotics. Fusidic acid works as the active anti-bacterial component of Fucicort Cream which performs its an...
Active ingredients- Phenylpropanolamine and Paracetamol.
Per capsule-phenylpropanolamine 25 mg and Paracetamol 325 mg.
Per 5 mL syrup- Paracetamol 240 mg and Phenylpropanolamine HCl 12.5 mg
Nasathera is from the family of systemic sympathomimetic preparatio...
Different vitamins found in our natural food are combined together to form multivitamins. When the regular meal fails to provide the required nutrients to the body multivitamin supplements are prescribed. In short Multivitamins are medicines use for treatment of vitamin defici...
Antamin (Chlorphenamine maleate)
Active ingredients- Chlorphenamine maleate
Antamin (Chlorphenamine maleate) belongs to the group of alternate alkylamines administered as general antihistamines.
The drug assists to alleviate signs of cold as well as allergy, lik...
Active ingredients- Acetylcysteine
Fluimucil (Acetylcysteine) is from the group of mucolytics administered for treating wet cough.
Fluimucil (Acetylcysteine) uses/ indications
It may be indicated for treating severe and chronic respiratory tract infection with plenty o...
Alvedon (Paracetamol) 500mg tablet
Active ingredients- paracetamol
Despite being used for over 100 years, research haven’t yet being able to understand the working of paracetamol, however it is presumed that Alvedon (Paracetamol) 500mg works by decreasing the secretion of prostaglandins in t...
While some people perform strenuous exercises or take diet pills to lose weight, there are also individuals who would want to gain extra pounds. Athletes for instance, would want more muscles and to do that they must take a lot of protein enriched foods. Parents would want their kids to eat more to ...
A lot of antitussive agents today act centrally and causes central adverse events such as sedation, vomiting, and nausea. Because of this, there has been a search for a peripherally-acting antitussive agent expected to not produce these central adverse effects. However, the peripherally-acting antit...
Ambroxol (mucosolvan) side effects
Ambroxol Hydrochloride is an effective expectorant administered for various respiratory problems. It is a medically proven active mucolytic agent. Ambroxol is used for treating respiratory tract infections and other lung infections, which includes inflammatory pul...
Methycobal Tablets (Mecobalamin 500 mcg)
Each Methycobal sugar coated Tablet contains: Mecobalamin 500 mcg (Appropriate overages added) Color: Titanium Dioxide
Methycobal is a mecobalamin drug, a co-enzyme of Vitamin B that transpires in the blood and the cerebrospinal fluid. It is utilized by the...
Biogesic (paracetamol) Side effects
Paracetamol is the generic name for Biogesic and use for treating moderate to severe pain, headache, fever, arthritis pain, and muscle ache. Biogesic tablets, though, does not alleviate the hardness, reddishness and inflammation linked to rheumatoid arthritis, bu...
Active ingredients- Paracetamol and Ibuprofen
Ibuprofen is a powerful anti-inflammatory with painkilling and antipyretic activity. Its antipyretic and analgesic actions are additionally reinstated by paracetamol.
Combiflam Adverse Reactions
Combiflam Side Eff...
SORBILINE (SORBITOL SOLUTION)
Each 10 ml of SORBILINE contains :
TR1CHOL1NE CITRATE 0.55 g
SORBITOL SOLUTION (70%) I.P. 7.15 g
Color : Sunset Yellow FCF (Colour Index 15985)
Elica cream (mometasone furoate cream)
Elica (mometasone furoate) Cream, 0.1%, is made up of mometasone furoate, USP for dermatologic use. Mometasone furoate is a artificial corticosteroid with anti- seditious action.
Each gram of Elica Cream, 0.1%, comprises: 1 mg mometasone furoate, USP in a c...
There are a lot of options available when you need to fill a prescription. Grocery store chains, superstore chains and traditional drug stores are on practically every block, ready, willing and able to supply you with your medicinal needs and good advice.
Comparing superstore and traditional ...
In various disorders such as acute and chronic bronchitis and other bronchospastic disorders such as eosinophilia, there is a spasm of the bronchial muscles and irritation of the bronchial mucous membrane, leading to breathlessness and cough. In the symptomatic management of these di...
Erythromycin is a drug of choice in a case when a patient is allergic to penicillin. However, using the same antibiotic may result to tolerance. Here are other antibiotic alternatives that are often prescribed by physician in replacement for Erythromycin.
Josamycin has been marke...